Amrinone
Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways.
primaryTopic
Amrinone
Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways.
has abstract
25بك المحتوى هنا ينقصه الاستشه ...... A والكالسيوم Ca+2 كالمودلين .
@ar
Amrinon ist ein im deutschen S ...... Kontraktionskraft des Herzens.
@de
Amrinone (INN) or inamrinone ( ...... 2+ calmodulin kinase pathways.
@en
Anrinona é um fármaco utilizad ...... ando atividade vasodilatadora.
@pt
アムリノン(Amrinone)とは強心薬の1つ。正確な作用機 ...... 禁忌。変力作用のある強心配糖体はアムリノンと相加作用がある。
@ja
ATC prefix
ATC suffix
CAS number
60719-84-8
DrugBank
FDA UNII code
JUT23379TN
IUPAC name
5-amino-3,4'-bipyridin-6(1H)-one
@en
PubChem
thumbnail
Wikipage page ID
Wikipage revision ID
743,914,515
bioavailability
ChEMBL
ChemSpiderID
elimination half-life
excretion
Renal and fecal
IUPHAR ligand
legal US
molecular weight
1.87198e+2
protein bound
smiles
O=C2C=C\C=C/N2
StdInChIKey
RNLQIBCLLYYYFJ-UHFFFAOYSA-N
tradename
verifiedrevid
443,387,938
subject
hypernym
comment
25بك المحتوى هنا ينقصه الاستشه ...... A والكالسيوم Ca+2 كالمودلين .
@ar
Amrinon ist ein im deutschen S ...... Kontraktionskraft des Herzens.
@de
Amrinone (INN) or inamrinone ( ...... 2+ calmodulin kinase pathways.
@en
Anrinona é um fármaco utilizad ...... ando atividade vasodilatadora.
@pt
アムリノン(Amrinone)とは強心薬の1つ。正確な作用機 ...... 禁忌。変力作用のある強心配糖体はアムリノンと相加作用がある。
@ja
label
Amrinon
@de
Amrinone
@en
Anrinona
@pt
أمرينون
@ar
アムリノン
@ja