BD1063
BD1063 or 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine. In other animal studies, BD1063 blocks the effects of MDMA, and reduces alcohol intake in rodent models of alcoholism.
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BD1063
BD1063 or 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine. In other animal studies, BD1063 blocks the effects of MDMA, and reduces alcohol intake in rodent models of alcoholism.
has abstract
BD1063 or 1-[2-(3,4-dichloroph ...... n rodent models of alcoholism.
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CAS number
150208-28-9
IUPAC name
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine
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Wikipage page ID
36,174,254
Wikipage revision ID
724,197,211
ChemSpiderID
molecular weight
smiles
CN1CCNCCc2cccCl
StdInChIKey
SUIZRDJCBVPASY-UHFFFAOYSA-N
subject
hypernym
comment
BD1063 or 1-[2-(3,4-dichloroph ...... n rodent models of alcoholism.
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label
BD1063
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