Befiradol
Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).
Befiradol
Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).
has abstract
Befiradol (F-13,640; NLX-112) ...... models of Parkinson's disease.
@en
Бефирадол (F-13,640; NLX-112) ...... инезий при болезни Паркинсона.
@ru
بيفيرادول (بالإنجليزية: Befira ...... كون بتواتر أقل أو عديم الحدوث.
@ar
ATC prefix
CAS number
208110-64-9
FDA UNII code
RAT9OHA1YH
IUPAC name
3-chloro-4-fluorophenyl-[4-flu ...... ethyl)piperidin-1-yl]methanone
@en
PubChem
thumbnail
Wikipage page ID
23,555,082
Wikipage revision ID
723,460,727
ChEMBL
ChemSpiderID
IUPHAR ligand
legal status
molecular weight
3.93857e+2
smiles
n2ccccc2CNCCCCN3Ccccc1F
StdInChIKey
PKZXLMVXBZICTF-UHFFFAOYSA-N
Verifiedfields
verifiedrevid
461,088,268
Watchedfields
comment
Befiradol (F-13,640; NLX-112) ...... from 84% to 124% (Ki=2.7 nM).
@en
Бефирадол (F-13,640; NLX-112) ...... 124 % от исходной (Ki=2.7 nM).
@ru
بيفيرادول (بالإنجليزية: Befira ...... كون بتواتر أقل أو عديم الحدوث.
@ar
label
Befiradol
@en
Бефирадол
@ru
بيفيرادول
@ar