Biphenylindanone A
Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2. In animal studies it showed anxiolytic and antipsychotic effects, and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.
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primaryTopic
Biphenylindanone A
Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2. In animal studies it showed anxiolytic and antipsychotic effects, and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.
has abstract
Biphenylindanone A (BINA, LS-1 ...... he mGluR2/3 agonist LY-379,268
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ATC prefix
IUPAC name
3’-(((2-cyclopentyl-6,7-dimeth ...... hyl)biphenyl-4-carboxylic acid
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PubChem
thumbnail
Wikipage page ID
19,393,048
Wikipage revision ID
724,240,094
ChEMBL
ChemSpiderID
IUPHAR ligand
molecular weight
4.54556e+2
smiles
c3ccccc3-ccc4COcccCC2C5CCCC5
StdInChIKey
KMKBEESNZAPKMP-UHFFFAOYSA-N
verifiedrevid
477,372,869
hypernym
comment
Biphenylindanone A (BINA, LS-1 ...... aditional antipsychotic drugs.
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label
Biphenylindanone A
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