The Blytheville Commercial Historic District encompasses most of the central business district of Blytheville, Arkansas, one of the two county seats of Mississippi County. It extends along Main Street between 5th and Franklin Streets, and along Ash Street between 5th and 2nd. Most of the 39 buildings in the district were built between 1890 and 1956, in three phases of development. The two oldest buildings in the district, both dating to c. 1890, are at 112 West Main and 106 East Main. The building traditionally viewed as the anchor of the downtown area is the Kirby-Heath building at the corner of Main and 2nd, built 1901.