The Cappadocian Fathers , also traditionally known as the Three Cappadocians, are Basil the Great (330–379), who was bishop of Caesarea; Basil's younger brother Gregory of Nyssa (c.332–395), who was bishop of Nyssa; and a close friend, Gregory of Nazianzus (329–389), who became Patriarch of Constantinople. Historically, this group only included these three figures given the traditional tendency in the ancient Church to exclude women, but an adjusted perspective supported by contemporaneous writings necessitates the inclusion of Macrina as an equal in the group, and therefore they should be referred to as "The Four Cappadocians." The Cappadocia region, in modern-day Turkey, was an early site of Christian activity, with several missions by Paul in this region.