Catalytic triad
A catalytic triad refers to the three amino acid residues that function together at the centre of the active site of some hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). An Acid-Base-Nucleophile triad is a common motif for generating a nucleophilic residue for covalent catalysis. The residues form a charge-relay network to polarise and activate the nucleophile, which attacks the substrate, forming a covalent intermediate which is then hydrolysed to regenerate free enzyme and release the product. The nucleophile is most commonly a serine or cysteine amino acid, but occasionally threonine. Because enzymes fold into complex three-dimensional structures, the residues of a catalytic triad can be far from each other along the amino-aci
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Catalytic triad
A catalytic triad refers to the three amino acid residues that function together at the centre of the active site of some hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). An Acid-Base-Nucleophile triad is a common motif for generating a nucleophilic residue for covalent catalysis. The residues form a charge-relay network to polarise and activate the nucleophile, which attacks the substrate, forming a covalent intermediate which is then hydrolysed to regenerate free enzyme and release the product. The nucleophile is most commonly a serine or cysteine amino acid, but occasionally threonine. Because enzymes fold into complex three-dimensional structures, the residues of a catalytic triad can be far from each other along the amino-aci
has abstract
A catalytic triad refers to th ...... best studied in biochemistry.
@en
Als katalytische Triade bezeic ...... äumliche Nähe gebracht werden.
@de
El término tríada catalítica r ...... udiados en toda la bioquímica.
@es
En biologie moléculaire, on dé ...... compris de toute la biochimie.
@fr
催化三联体通常指在水解酶和转移酶的活性位点中心同时作用的三个 ...... 方法。生物化学中，研究得最透彻之一的就是这些反应的作用机理。
@zh
触媒三残基（しょくばいさんざんき、英: Catalytic ...... H基が102番のアスパラギン酸のカルボキシ基に近接している。
@ja
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731,789,865
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Evolutionary convergence of se ...... ase, TEV protease, and papain.
Evolutionary convergence of th ...... d ornithine acetyltransferase.
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A catalytic triad refers to th ...... each other along the amino-aci
@en
Als katalytische Triade bezeic ...... ichen eine kovalente Katalyse.
@de
El término tríada catalítica r ...... veces puede ser una treonina.
@es
En biologie moléculaire, on dé ...... t également être la thréonine.
@fr
催化三联体通常指在水解酶和转移酶的活性位点中心同时作用的三个 ...... 方法。生物化学中，研究得最透彻之一的就是这些反应的作用机理。
@zh
触媒三残基（しょくばいさんざんき、英: Catalytic ...... H基が102番のアスパラギン酸のカルボキシ基に近接している。
@ja
label
Catalytic triad
@en
Katalytische Triade
@de
Triade catalytique
@fr
Tríada catalítica
@es
催化三联体
@zh
触媒三残基
@ja
