The Chicago, Milwaukee, and St. Paul Railroad-Grafton Station, also known as Grafton Depot, is a historic structure located in Grafton, Iowa, United States. The town of Grafton was surveyed and platted by the Chicago, Milwaukee and St. Paul Railroad in 1878, and the depot was completed by the railroad the following year. The railroad was important to the economic life of the town as it was the main source for receiving consumer goods and selling agricultural products, which was the area's primary industry. The depot closed in October 1974, one of the last small town depots to close in Iowa. It was listed on the National Register of Historic Places in 1976. The former depot was refurbished and it now houses a local history museum.