The Clarendon Methodist-Episcopal Church South is a historic church at 121 Third Street in Clarendon, Arkansas. It is a two-story brick structure with a cross-gable configuration, that has a dome at the crossing point of the gables. Single-story classroom and office wings flank the main block. The church was built in 1912, and was designed by John Gaisford, who produced a number of designs for Episcopal Church South congregations between 1905 and 1918. It is one of Clarendon's oldest church buildings, and one of its most impressive Classical Revival structures.