Clodronic acid
Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-alfa. While bisphosphonates are shown to be effective in reducing vertebral fractures and pain, their role in improving overall survival remains unclear.
primaryTopic
Clodronic acid
Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-alfa. While bisphosphonates are shown to be effective in reducing vertebral fractures and pain, their role in improving overall survival remains unclear.
has abstract
Clodronic acid (INN) or clodro ...... has too many adverse effects.
@en
L'acide clodronique (DCI) ou c ...... de Bonefos, Loron and Clodron.
@fr
L'acido clodronico o clodronat ...... o come medicinale equivalente.
@it
Клодро́новая кислота́ (МНН) ил ...... и агента антигиперкальциемии.
@ru
氯膦酸(Clodronic acid)是一種用來調節身體內鈣 ...... 吐、腹瀉、皮膚過敏等。(若以上之情況持續不改善應立即就醫。)
@zh
ATC prefix
ATC suffix
CAS number
10596-23-3
ChEBI
DrugBank
FDA UNII code
0813BZ6866
IUPAC name
(Dichloro-phosphono-methyl)phosphonic acid
@en
PubChem
thumbnail
Wikipage page ID
12,115,953
Wikipage revision ID
735,360,723
ChEMBL
ChemSpiderID
molecular weight
2.44892e+2
StdInChIKey
ACSIXWWBWUQEHA-UHFFFAOYSA-N
verifiedrevid
476,996,903
comment
Clodronic acid (INN) or clodro ...... rall survival remains unclear.
@en
L'acide clodronique (DCI) ou c ...... de Bonefos, Loron and Clodron.
@fr
L'acido clodronico o clodronat ...... o come medicinale equivalente.
@it
Клодро́новая кислота́ (МНН) ил ...... и агента антигиперкальциемии.
@ru
氯膦酸(Clodronic acid)是一種用來調節身體內鈣 ...... 吐、腹瀉、皮膚過敏等。(若以上之情況持續不改善應立即就醫。)
@zh
label
Acide clodronique
@fr
Acido clodronico
@it
Clodronic acid
@en
Клодроновая кислота
@ru
氯膦酸
@zh