Clomestrone
Clomestrone (brand names Arterolo, Atheran, Colesterel, Iposclerone, Liprotene, Persclerol, others; former developmental code name SC-8246), also known as 16α-chloroestrone 3-methyl ether, is a semisynthetic, steroidal, weak estrogen derived from estrone and used as an anticholesterolemic agent in the treatment of atherosclerosis. It is said to have beneficial effects on serum lipid profiles while producing minimal feminization, though some estrogenic side effects, including breast tenderness, loss of libido, and fatigue or avolition, were observed in most patients in clinical studies. The drug is a close analogue of mytatrienediol, and the two estrogens have similar drug profiles. Clomestrone was described in the literature in 1958 and introduced for medical use shortly thereafter.
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primaryTopic
Clomestrone
Clomestrone (brand names Arterolo, Atheran, Colesterel, Iposclerone, Liprotene, Persclerol, others; former developmental code name SC-8246), also known as 16α-chloroestrone 3-methyl ether, is a semisynthetic, steroidal, weak estrogen derived from estrone and used as an anticholesterolemic agent in the treatment of atherosclerosis. It is said to have beneficial effects on serum lipid profiles while producing minimal feminization, though some estrogenic side effects, including breast tenderness, loss of libido, and fatigue or avolition, were observed in most patients in clinical studies. The drug is a close analogue of mytatrienediol, and the two estrogens have similar drug profiles. Clomestrone was described in the literature in 1958 and introduced for medical use shortly thereafter.
has abstract
Clomestrone (brand names Arter ...... edical use shortly thereafter.
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CAS number
FDA UNII code
P1L5F7667L
IUPAC name
(8R,9S,13S,14S,16R)-16-Chloro- ...... yclopenta[a]phenanthren-17-one
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PubChem
thumbnail
Wikipage page ID
51,601,254
Wikipage revision ID
741,862,919
ChemSpiderID
molecular weight
3.1883772e+2
smiles
CC12CCC3CCCC4=C3C=CCOC
StdInChIKey
UQIPVSBPFZSWGD-ILYVXUQDSA-N
synonyms
comment
Clomestrone (brand names Arter ...... edical use shortly thereafter.
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label
Clomestrone
@en