Coenzyme B

Coenzyme B is a coenzyme required for redox reactions in methanogens. The full chemical name of coenzyme B is 7-mercaptoheptanoylthreoninephosphate. The molecule contains a thiol, which is its principal site of reaction. Coenzyme B reacts with 2-methylthioethanesulfonate (methyl-Coenzyme M, abbreviated CH3–S–CoM), to release methane in methanogenesis: CH3–S–CoM + HS–CoB → CH4 + CoB–S–S–CoM This conversion is catalyzed by the enzyme methyl coenzyme M reductase, which contains cofactor F430 as the prosthetic group. CH3–S–CoM + HS–CoB −O2CCH=CHCO−2 → −O2CCH2–CH2CO−2 + CoB–S–S–CoM

Coenzyme B

Coenzyme B is a coenzyme required for redox reactions in methanogens. The full chemical name of coenzyme B is 7-mercaptoheptanoylthreoninephosphate. The molecule contains a thiol, which is its principal site of reaction. Coenzyme B reacts with 2-methylthioethanesulfonate (methyl-Coenzyme M, abbreviated CH3–S–CoM), to release methane in methanogenesis: CH3–S–CoM + HS–CoB → CH4 + CoB–S–S–CoM This conversion is catalyzed by the enzyme methyl coenzyme M reductase, which contains cofactor F430 as the prosthetic group. CH3–S–CoM + HS–CoB −O2CCH=CHCO−2 → −O2CCH2–CH2CO−2 + CoB–S–S–CoM