Colony's Block is a historic commercial building at 4-7 Central Square in the heart of Keene, New Hampshire. The five story brick building was built in 1870 to a design by Worcester, Massachusetts architects E. Boyden & Son. The owners were Henry and Alfred T. Colony, whose family controlled the Cheshire Mills. The building is one of the most imposing buildings on Central Square, and is an elaborate example of Second Empire styling. The building was listed on the National Register of Historic Places in 1983.