Cycloguanil
Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.
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primaryTopic
Cycloguanil
Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.
has abstract
Cycloguanil is a dihydrofolate ...... combination with other drugs.
@en
Il cicloguanil è un metabolita ...... ombinazione con altri farmaci.
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ATC prefix
ATC suffix
CAS number
FDA UNII code
26RM326WVN
IUPAC name
1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
@en
PubChem
thumbnail
Wikipage page ID
12,573,921
Wikipage revision ID
713,199,580
ChemSpiderID
molecular weight
2.51715e+2
smiles
StdInChIKey
QMNFFXRFOJIOKZ-UHFFFAOYSA-N
verifiedrevid
443,546,900
Watchedfields
hypernym
comment
Cycloguanil is a dihydrofolate ...... rofolate reductase inhibition.
@en
Il cicloguanil è un metabolita ...... della diidrofolato reduttasi.
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label
Cicloguanil
@it
Cycloguanil
@en