DIMP (antiandrogen)
DIMP (developmental code name Ro 7-8117), or N-(3,5-dimethyl-4-isoxazolylmethyl)phthalimide, is a non-steroidal antiandrogen (NSAA) structurally related to thalidomide (which also binds to and antagonizes the androgen receptor (AR)) that was first described in 1973 and was never marketed. Along with flutamide, it was one of the earliest NSAAs to be discovered, and for this reason, has been described as a "classical" NSAA. The drug is a selective, competitive, silent antagonist of the AR, although it is described as an "only relatively weak competitor". DIMP possesses no androgenic, estrogenic, progestogenic, or antigonadotropic activity, but it does reverse the antigonadotropic effects of testosterone, indicating that, like other pure AR antagonists, it is progonadotropic.
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primaryTopic
DIMP (antiandrogen)
DIMP (developmental code name Ro 7-8117), or N-(3,5-dimethyl-4-isoxazolylmethyl)phthalimide, is a non-steroidal antiandrogen (NSAA) structurally related to thalidomide (which also binds to and antagonizes the androgen receptor (AR)) that was first described in 1973 and was never marketed. Along with flutamide, it was one of the earliest NSAAs to be discovered, and for this reason, has been described as a "classical" NSAA. The drug is a selective, competitive, silent antagonist of the AR, although it is described as an "only relatively weak competitor". DIMP possesses no androgenic, estrogenic, progestogenic, or antigonadotropic activity, but it does reverse the antigonadotropic effects of testosterone, indicating that, like other pure AR antagonists, it is progonadotropic.
has abstract
DIMP (developmental code name ...... ved from DIMP and thalidomide.
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CAS number
39962-28-2
IUPAC name
2-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione
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PubChem
thumbnail
Wikipage page ID
51,305,259
Wikipage revision ID
743,608,380
ChEMBL
ChemSpiderID
molecular weight
2.5625668e+2
smiles
CC1=CCN2CC3=CC=CC=C3C2=O
StdInChIKey
SHPRUADECKZSMQ-UHFFFAOYSA-N
synonyms
Ro 7-8117; N-phthalimide
comment
DIMP (developmental code name ...... onists, it is progonadotropic.
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label
DIMP (antiandrogen)
@en