DePaul Catholic High School is a private, Roman Catholic high school in Wayne, in Passaic County, New Jersey, United States, that operates under the auspices of the Roman Catholic Diocese of Paterson. The school has been accredited by the Middle States Association of Colleges and Schools Commission on Secondary Schools since 1989. As of the 2013-14 school year, the school had an enrollment of 665 students and 60.6 classroom teachers (on an FTE basis), for a student–teacher ratio of 11.0:1.