Dimetacrine
Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).
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Dimetacrine
Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).
has abstract
Dimetacrine (Istonil, Istonyl, ...... lic class of antidepressants).
@en
ジメタクリン(Dimetacrine)またはアクリプラミン( ...... 、ジメタクリンを過量摂取すると心臓に対する深刻な毒性となる。
@ja
ATC prefix
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FDA UNII code
O341NY501N
IUPAC name
3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
@en
PubChem
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Wikipage page ID
23,294,749
Wikipage revision ID
725,069,274
Alt
Ball-and-stick model of the dimetacrine molecule
Skeletal formula of dimetacrine
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legal status
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routes of administration
hypernym
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Dimetacrine (Istonil, Istonyl, ...... lic class of antidepressants).
@en
ジメタクリン(Dimetacrine)またはアクリプラミン( ...... 、ジメタクリンを過量摂取すると心臓に対する深刻な毒性となる。
@ja
label
Dimetacrine
@en
ジメタクリン
@ja