The Enterprise Building is an historic commercial building at 540 Main Street in Worcester, Massachusetts. When it was built in 1900, this five story brick building achieved notice for its elaborate Beaux Arts decorations. The building was designed by Fuller & Delano, and includes as features limestone cartouches on the fourth story terracotta window surrounds and swag panels on the fifth story, and a pressed metal cornice. The building was listed on the National Register of Historic Places in 1980.