Follicular atresia

Follicular atresia is inhibited by follicle-stimulating hormone (FSH), which promotes follicle development. Once the follicle has developed, it secretes estrogen, which in high levels decreases secretions of FSH. Granulosa cell apoptosis is considered the underlying mechanism of follicular atresia, and has been associated with five ligand-receptor systems involved in cell death: * Tumor necrosis factor alpha (TNFα) and receptors * Fas ligand and receptors * TNF-related apoptosis-inducing ligand (TRAIL or APO-2) and receptors * APO-3 ligand and receptors * PFG-5 ligand and receptors

Follicular atresia

Follicular atresia is inhibited by follicle-stimulating hormone (FSH), which promotes follicle development. Once the follicle has developed, it secretes estrogen, which in high levels decreases secretions of FSH. Granulosa cell apoptosis is considered the underlying mechanism of follicular atresia, and has been associated with five ligand-receptor systems involved in cell death: * Tumor necrosis factor alpha (TNFα) and receptors * Fas ligand and receptors * TNF-related apoptosis-inducing ligand (TRAIL or APO-2) and receptors * APO-3 ligand and receptors * PFG-5 ligand and receptors