Franz Bruno Hofmann (24 November 1869, Skalka – 6 June 1926, Marburg) was an Austrian-German physiologist. In 1894 he received his medical doctorate from the German University in Prague, and for several years worked as an assistant to physiologist Ewald Hering, first in Prague (1893–95), then afterwards at the University of Leipzig (1895–1905). At Leipzig, with ophthalmologist Alfred Bielschowsky, he conducted studies on fusion and cyclodeviation in paresis of the superior oblique muscle as well as on congenital hyperfunction of the superior oblique muscle.