Charley Brewster is an average teenager who finds his world turned upside-down when vampire Jerry Dandrige moves in next door. He enlists the aid of horror movie star/TV host Peter Vincent to kill Dandrige and they're successful—but not before Charley's best friend, Evil Ed, is transformed into a bloodthirsty monster whom delights in tormenting his former buddy. Soon Peter and Charley team up to fend off a variety of monsters, including squid-men, a spider boy, aliens, a minotaur, an evil sorceress and the nefarious Legion of the Endless Night, a vampire coven which later resurrects Jerry Dandrige.