GlmS glucosamine-6-phosphate activated ribozyme
The Glucosamine-6-phosphate activated ribozyme ( glmS ribozyme) is an RNA structure that is both a ribozyme, since it catalyzes a chemical reaction, and a riboswitch, since it regulates genes in response to concentrations of a metabolite.It was originally identified using bioinformatics in the 5' untranslated regions of glmS genes.The GlmS enzyme catalyzes the production of glucosamine-6-phosphate (GlcN6P), and the glmS ribozyme is dependent on GlcN6P to achieve catalysis of its own cleavage. This cleavage leads to the degradation of the mRNA that contains the ribozyme, and ultimately lowers production of the GlmS enzyme, encoded by the glmS gene. The GlmS enzyme catalyzes the reaction to synthesize GlcN6P, so it is not required when GlcN6P levels are already high. When GlcN6P levels are l
primaryTopic
GlmS glucosamine-6-phosphate activated ribozyme
The Glucosamine-6-phosphate activated ribozyme ( glmS ribozyme) is an RNA structure that is both a ribozyme, since it catalyzes a chemical reaction, and a riboswitch, since it regulates genes in response to concentrations of a metabolite.It was originally identified using bioinformatics in the 5' untranslated regions of glmS genes.The GlmS enzyme catalyzes the production of glucosamine-6-phosphate (GlcN6P), and the glmS ribozyme is dependent on GlcN6P to achieve catalysis of its own cleavage. This cleavage leads to the degradation of the mRNA that contains the ribozyme, and ultimately lowers production of the GlmS enzyme, encoded by the glmS gene. The GlmS enzyme catalyzes the reaction to synthesize GlcN6P, so it is not required when GlcN6P levels are already high. When GlcN6P levels are l
has abstract
The Glucosamine-6-phosphate ac ...... tion as an acid-base catalyst.
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Wikipage page ID
11,420,863
Wikipage revision ID
722,960,856
Caption
Predicted secondary structure and sequence conservation of glmS
name
glmS glucosamine-6-phosphate activated ribozyme
RNA type
Tax domain
hypernym
type
comment
The Glucosamine-6-phosphate ac ...... high. When GlcN6P levels are l
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label
GlmS glucosamine-6-phosphate activated ribozyme
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