Head and neck cancer are a group that start in the head and neck. Most originate from the mucosa, occurring in upper airway and digestive tract. A subset containing sequences of human papillomavirus (HPV), which differ in biological and clinical features and molecular pathogenesis (gene expression, mutations, amplifications and deletions and alterations epigenome) with respect to non driven by the virus. Depending on the anatomic location of the tumor, HPV prevalence is estimated between 23 and 36%.