State Road 64 in the U.S. State of Indiana is an east–west highway that crosses most of the southern portion of the state, covering a distance of about 107 miles (172 km). The route parallels Interstate 64, which often causes confusion, as the widest distance between them is 20 miles at the Wabash River, and both routes exist in Crawford, Dubois, Floyd, Gibson, and Harrison Counties. It is often referred to as Indiana 64 to distinguish it from the Interstate.