Irreversible antagonist
An irreversible antagonist is a type of antagonist that binds permanently to a receptor, either by forming a covalent bond to the active site, or alternatively just by binding so tightly that the rate of dissociation is effectively zero at relevant time scales. This permanently deactivates the receptor and is usually followed by rapid internalisation and recycling of the non-functional receptor protein. Irreversible enzyme inhibitors that act similarly are clinically used and include drugs such as aspirin, omeprazole and monoamine oxidase inhibitors.
primaryTopic
Irreversible antagonist
An irreversible antagonist is a type of antagonist that binds permanently to a receptor, either by forming a covalent bond to the active site, or alternatively just by binding so tightly that the rate of dissociation is effectively zero at relevant time scales. This permanently deactivates the receptor and is usually followed by rapid internalisation and recycling of the non-functional receptor protein. Irreversible enzyme inhibitors that act similarly are clinically used and include drugs such as aspirin, omeprazole and monoamine oxidase inhibitors.
has abstract
An irreversible antagonist is ...... monoamine oxidase inhibitors.
@en
Un antagonista irreversible es ...... dores de la monoamino oxidasa.
@es
Необратимые антагонисты ковале ...... и уменьшение максимума кривой.
@ru
不可逆拮抗剂是一种永久与受体结合的拮抗剂。它要么与活性位点形 ...... 不可逆酶抑制剂药物,如阿司匹林、奥美拉唑和单胺氧化酶抑制剂。
@zh
Wikipage page ID
23,590,452
Wikipage revision ID
535,442,892
subject
hypernym
type
comment
An irreversible antagonist is ...... monoamine oxidase inhibitors.
@en
Un antagonista irreversible es ...... dores de la monoamino oxidasa.
@es
Необратимые антагонисты ковале ...... оров является феноксибензамин,
@ru
不可逆拮抗剂是一种永久与受体结合的拮抗剂。它要么与活性位点形 ...... 不可逆酶抑制剂药物,如阿司匹林、奥美拉唑和单胺氧化酶抑制剂。
@zh
label
Antagonista irreversible
@es
Irreversible antagonist
@en
Необратимый антагонист
@ru
不可逆拮抗剂
@zh