The Jacob P. Mesick House is located on Van Wyck Lane in Claverack, New York, United States. It is a wooden house in the Greek Revival architectural style built in the mid-19th century. It is a strong example of that style in the region that has remained intact since its construction, with its original front facade restored in the early 20th century. Jacob Mesick, its builder and first resident, was a prosperous local farmer who later went into politics. The house has remained in family hands. In 1997 it was listed on the National Register of Historic Places.