The Knoxville Iron Company was an iron production and coal mining company that operated primarily in Knoxville, Tennessee, United States, and its vicinity, in the late 19th and 20th centuries. The company was Knoxville's first major post-Civil War manufacturing firm, and played a key role in bringing heavy industry and railroad facilities to the city. The company was also the first to conduct major coal mining operations in the lucrative coalfields of western Anderson County, and helped establish one of Knoxville's first residential neighborhoods, Mechanicsville, in the late 1860s.