Lowther Store, also known as the John A. Hinkle and Son Store, is a historic general store located near Wheeler, Webster County, West Virginia. It was built about 1900 and expanded about 1910. The store is a one-story rectangular, wood-frame building with a foundation of field stones and posts. Also on the property are a frame coal house, and a storage building located across the roadway. It is the oldest continuous operating business in Webster County. It was listed on the National Register of Historic Places in 1997.