Luzerne Township is a township in Fayette County, Pennsylvania, United States. The population was 5,965 at the 2010 census, up from 4,683 at the 2000 census. The unincorporated communities of East Millsboro, La Belle, Hiller, Isabella, Luzerne, Dutch Hill, Maxwell, Allison, Alicia, East Fredericktown and Penncraft are located within the township. La Belle, Luzerne, Dutch Hill, Maxwell and East Fredericktown are served by the post office in La Belle and thus have the same ZIP code (15450), as does SCI Fayette, a Pennsylvania state prison located next to East Fredericktown.