MFZ 10-7
MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP & MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.
primaryTopic
MFZ 10-7
MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP & MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.
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MFZ 10-7 (3-fluoro-5-((6-methy ...... animal administration models.
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IUPAC name
3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile
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51,193,638
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732,165,827
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MFZ 10-7 (3-fluoro-5-((6-methy ...... animal administration models.
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label
MFZ 10-7
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