Machado–Joseph disease
Machado–Joseph disease (MJD), also known as Machado–Joseph Azorean disease or Joseph's disease or spinocerebellar ataxia type 3 (SCA3), is a rare autosomal dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia, which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness or Parkinson's disease.
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Machado–Joseph disease
Machado–Joseph disease (MJD), also known as Machado–Joseph Azorean disease or Joseph's disease or spinocerebellar ataxia type 3 (SCA3), is a rare autosomal dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia, which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness or Parkinson's disease.
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Doença de Machado-Joseph (DMJ) ...... hecida por doença do tropeção.
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La maladie de Machado-Joseph e ...... générescence nerveuse limitée.
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Machado–Joseph disease (MJD), ...... sensory and cerebellar ataxia.
@en
マチャド・ジョセフ病(マシャド・ジョセフ病、Machado- ...... 因遺伝子が同じものと明らかになってからは区別されなくなった。
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744,397,931
DiseasesDB
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Doença de Machado-Joseph (DMJ) ...... culdades na fala e no engolir.
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La maladie de Machado-Joseph e ...... générescence nerveuse limitée.
@fr
Machado–Joseph disease (MJD), ...... enness or Parkinson's disease.
@en
マチャド・ジョセフ病(マシャド・ジョセフ病、Machado- ...... 因遺伝子が同じものと明らかになってからは区別されなくなった。
@ja
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Doença de Machado-Joseph
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Machado–Joseph disease
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Maladie de Machado-Joseph
@fr
マチャド・ジョセフ病
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Machado-Joseph disease
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