Mary Hancock McLean (28 February 1861 - 17 May 1930) was a physician and missionary. Born to Elijah McLean, a physician, and Mary Stafford, she enjoyed a privileged childhood with academic opportunities uncommon for girls of her time period. After graduating from the University of Michigan Medical School, she became the first woman to hold an official position at the St. Louis Female Hospital and first woman admitted to the St. Louis Medical Society. She practiced medicine until five months before her death and died on May 17, 1930 in St. Louis having never married.