Merchants National Bank is a bank building in Winona, Minnesota, United States, designed in the Prairie School architectural style. It was built in 1912 and features elaborate terracotta and stained-glass ornamentation. It was listed on the National Register of Historic Places in 1974 for having state-level significance in the themes of architecture and commerce. It was nominated for being the "largest and probably best example" of the 18 Midwestern banks designed by Purcell, Feick & Elmslie, a significant influence on early-20th-century American architecture. It is also a contributing property to the Winona Commercial Historic District.