Mesembrenone
Mesembrenone is an alkaloid constituent of Sceletium tortuosum (Kanna). Similar to modern synthetic antidepressants, it is a potent (IC50 < 1 μM) selective inhibitor of the serotonin transporter (SERT) (that is, a selective serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).
primaryTopic
Mesembrenone
Mesembrenone is an alkaloid constituent of Sceletium tortuosum (Kanna). Similar to modern synthetic antidepressants, it is a potent (IC50 < 1 μM) selective inhibitor of the serotonin transporter (SERT) (that is, a selective serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).
has abstract
Mesembrenona es un alcaloide c ...... PDE4) inhibidor (Ki = 470 nM).
@es
Mesembrenone is an alkaloid co ...... PDE4) inhibitor (Ki = 470 nM).
@en
IUPAC name
(3aR,7aS)-3a-(3,4-Dimethoxyphenyl)-1-methyl-1,2,3,3a,7,7a-hexahydro-6H-indol-6-one
@en
thumbnail
Wikipage page ID
38,459,955
Wikipage revision ID
721,451,161
ImageFile
imagesize
hypernym
comment
Mesembrenona es un alcaloide c ...... PDE4) inhibidor (Ki = 470 nM).
@es
Mesembrenone is an alkaloid co ...... PDE4) inhibitor (Ki = 470 nM).
@en
label
Mesembrenona
@es
Mesembrenone
@en