Naegleria gruberi is a species of Naegleria. It is famous for its ability to change from an amoeba, which lacks a cytoplasmic microtubule cytoskeleton, to a flagellate, which has an elaborate microtubule cytoskeleton, including flagella. This "transformation" includes de novo synthesis of basal bodies (or centrioles). It was first characterized in 1899, and the genome sequence published in 2010. Naegleria gruberi has been experimentally shown to be non pathogenic, although it is related to several pathogenic Naegleria species, including Naegleria fowleri.