The Nanticoke Lodge No. 172, A.F. and A.M. is a historic mixed-use commercial building at 112-116 North Main Street in Federalsburg, Maryland. The two story terra cotta brick building was erected in 1919-20 by local Masonic groups. It housed retail operations on the first floor, and a large auditorium for lodge functions on the second. It is one of two surviving purpose-built Masonic buildings in the Caroline County. Its upper floor lodge spaces have well-preserved period detailing. The building was listed on the National Register of Historic Places in 2014.