Nephele oenopion is a moth of the family Sphingidae. It is known from Africa. The length of the forewings is 38–40 mm. The abdomen upperside has black patches. The forewing upperside has a small white basal dot. The basal band is irregular, olive-green to mid-green, edged with white basally and distally. The postmedian band is straight, broad and narrowing slightly toward the inner margin, which it meets at right angles. The inner margin between the basal and postmedian bands is edged with white. The discal spot is a minute white dot. The larvae feed on Mussaenda arcuata.