Norfenfluramine
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe, as both fenfluramine and benfluorex form norfenfluramine as an active metabolite. It is a human TAAR1 agonist.
primaryTopic
Norfenfluramine
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe, as both fenfluramine and benfluorex form norfenfluramine as an active metabolite. It is a human TAAR1 agonist.
has abstract
La norfenfluramine (3-trifluor ...... (Mediator), retirés du marché.
@fr
Norfenfluramine, or 3-trifluor ...... . It is a human TAAR1 agonist.
@en
ノルフェンフルラミン(Norfenfluramine)または ...... られなくなった。ヒトのTAAR1のアゴニストとして作用する。
@ja
IUPAC name
1-[3-(Trifluoromethyl)phenyl]propan-2-amine
@en
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Wikipage page ID
12,864,642
Wikipage revision ID
723,679,425
ImageAlt
Ball-and-stick model of the norfenfluramine molecule
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othernames
verifiedrevid
422,837,453
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La norfenfluramine (3-trifluor ...... is-à-vis des récepteurs 5HT2B,
@fr
Norfenfluramine, or 3-trifluor ...... . It is a human TAAR1 agonist.
@en
ノルフェンフルラミン(Norfenfluramine)または ...... られなくなった。ヒトのTAAR1のアゴニストとして作用する。
@ja
label
Norfenfluramine
@en
Norfenfluramine
@fr
ノルフェンフルラミン
@ja