OAS1
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been describ
OAS1
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been describ
has abstract
2'-5'-oligoadenylate synthetas ...... isoforms have been described.
@en
Die Oligoadenylatsynthetase 1 ...... n Resistenzfaktor gegen Viren.
@de
Wikipage page ID
14,166,840
Wikipage revision ID
723,520,045
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2'-5'-oligoadenylate synthetas ...... ent isoforms have been describ
@en
Die Oligoadenylatsynthetase 1 ...... n Resistenzfaktor gegen Viren.
@de
label
OAS1
@en
Oligoadenylatsynthetase 1
@de