Oregon Route 38 is an Oregon state highway that runs between the city of Reedsport, on the Oregon Coast, and an interchange with Interstate 5 near the communities of Curtin and Anlauf. It is also known as most of as the Umpqua Highway No. 45 (see Oregon highways and routes), as the western portions of the highway run alongside the Umpqua River. The highway lies entirely within Douglas County.