The Orto Botanico dell'Università di Cagliari (5 hectares), also known as the Orto Botanico di Cagliari, is a botanical garden operated by the University of Cagliari and located at Viale S. Ignazio da Laconi 9-11, Cagliari, Sardinia, Italy. The garden was inaugurated in 1866 under the direction of Prof. Patrizio Gennari. Its first seed index was published in 1885, and by 1901 the garden contained some 430 species (of which 36 were killed by that year's deep frost). The garden was damaged in World War II but has subsequently been restored.