The Piney Creek Wilderness is an 8,122-acre (33 km2) wilderness area in Missouri. The United States Congress designated it wilderness in 1980. The Piney Creek Wilderness is located within the Ava-Cassville-Willow Springs Ranger District of the Mark Twain National Forest, east of Cassville, Missouri. The area is named after Piney Creek, which runs the length of the wilderness area, an eventually empties into the James River arm of Table Rock Lake. The Piney Creek Wilderness is one of eight wilderness areas of the Mark Twain National Forest that are protected and preserved in Missouri.