Rimcazole
Rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor. Sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications. Rimcazole has been shown to reduce the effects of cocaine, and analogues of rimcazole have been shown to be highly effective at blocking the convulsions caused by cocaine overdose in animal models.
Rimcazole
Rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor. Sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications. Rimcazole has been shown to reduce the effects of cocaine, and analogues of rimcazole have been shown to be highly effective at blocking the convulsions caused by cocaine overdose in animal models.
has abstract
Rimcazole is an antagonist of ...... ine overdose in animal models.
@en
ATC prefix
CAS number
75859-04-0
FDA UNII code
C3N1PS8CX1
IUPAC name
9-{3-[(3R,5S)-3,5-Dimethylpiperazin-1-yl]propyl}-9H-carbazole
@en
PubChem
thumbnail
Wikipage page ID
12,286,243
Wikipage revision ID
723,845,250
ChEMBL
ChemSpiderID
molecular weight
3.21459e+2
smiles
C[C@@H]1CNCCCN2C3=CC=CC=C3C4=CC=CC=C42
StdInChIKey
GUDVQJXODNJRIJ-CALCHBBNSA-N
Verifiedfields
verifiedrevid
387,268,762
Watchedfields
hypernym
comment
Rimcazole is an antagonist of ...... ine overdose in animal models.
@en
label
Rimcazole
@en