S-phase-promoting factor
The S-phase-promoting factor (SPF) is a CDK-cyclin complex that induces the S-phase (synthesis phase) of the cell cycle. The S-phase-promoting factor (SPF) is inhibited by Sic1 (a protein which also is a stoichiometric inhibitor of Cdk1-Clb, B-type cyclins).Sic1 releases SPF from inhibition after it is phosphorylated by G1-cyclin-CDK. The phosphorylation marking SPF for polyubiquitination by the SCF ubiquitin ligase. Then the active SPF trigger initiation of DNA synthesis.
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S-phase-promoting factor
The S-phase-promoting factor (SPF) is a CDK-cyclin complex that induces the S-phase (synthesis phase) of the cell cycle. The S-phase-promoting factor (SPF) is inhibited by Sic1 (a protein which also is a stoichiometric inhibitor of Cdk1-Clb, B-type cyclins).Sic1 releases SPF from inhibition after it is phosphorylated by G1-cyclin-CDK. The phosphorylation marking SPF for polyubiquitination by the SCF ubiquitin ligase. Then the active SPF trigger initiation of DNA synthesis.
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The S-phase-promoting factor ( ...... iation of the G1/S transition.
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713,181,783
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The S-phase-promoting factor ( ...... r initiation of DNA synthesis.
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S-phase-promoting factor
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