The Shire of Isis was a local government area located in the Wide Bay–Burnett region of Queensland, Australia, to the south of Bundaberg. The Shire, administered from the town of Childers covered an area of 1,702.2 square kilometres (657.2 sq mi), and existed as a local government entity from 1887 until 2008, when it was amalgamated with the City of Bundaberg and the Shires of Burnett and Kolan to form the Bundaberg Region.