Spirorenone
Spirorenone (INN) (developmental code name ZK-35973) is a steroidal antimineralocorticoid of the spirolactone group that was never marketed. Spirorenone possesses 5–8 times the antimineralocorticoid activity of spironolactone in animal studies. The initial discovery of spirorenone was deemed a great success, as no compound with greater antimineralocorticoid activity had been developed since spironolactone in 1957. Moreover, spirorenone itself has virtually no affinity for the androgen receptor while its progestogenic activity shows species differences, being somewhat greater than that of spironolactone in rabbits but absent in mice and rats. As such, it was characterized as a highly potent antimineralocorticoid with far fewer hormonal side effects relative to spironolactone.
primaryTopic
Spirorenone
Spirorenone (INN) (developmental code name ZK-35973) is a steroidal antimineralocorticoid of the spirolactone group that was never marketed. Spirorenone possesses 5–8 times the antimineralocorticoid activity of spironolactone in animal studies. The initial discovery of spirorenone was deemed a great success, as no compound with greater antimineralocorticoid activity had been developed since spironolactone in 1957. Moreover, spirorenone itself has virtually no affinity for the androgen receptor while its progestogenic activity shows species differences, being somewhat greater than that of spironolactone in rabbits but absent in mice and rats. As such, it was characterized as a highly potent antimineralocorticoid with far fewer hormonal side effects relative to spironolactone.
has abstract
Spirorenone (INN) (development ...... ed instead as a contraceptive.
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ATC prefix
CAS number
74220-07-8
FDA UNII code
B8TEV07170
IUPAC name
(1aR,5aR,5bS,7aS,8S,8aS,9aS,9b ...... ,2'-furan]-3,5'(4'H,5aH)-dione
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PubChem
thumbnail
Wikipage page ID
50,695,517
Wikipage revision ID
742,856,275
ChEMBL
ChemSpiderID
molecular weight
3.6447732e+2
routes of administration
smiles
CC12CCC3CC6CC6C7=CCC=CC37C
StdInChI
InChI=1S/C24H28O3/c1-22-6-3-12 ...... ,18+,20-,21+,22-,23+,24+/m1/s1
StdInChIKey
NZUIUYWHFPQZBH-HXCATZOESA-N
comment
Spirorenone (INN) (development ...... ts relative to spironolactone.
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label
Spirorenone
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