Stuart Uptown Historic District is a national historic district located at Stuart, Patrick County, Virginia. The district includes 18 contributing buildings and 1 contributing object in the central business district of the town of Stuart. The district includes a variety of commercial and governmental buildings including the Stuart Post Office constructed by the Public Works Administration in 1940, the Patrick County Bank (1911), Bank of Stuart (1896), Stuart United Methodist Church and the Stuart Baptist Church. The district includes one and two-story brick commercial buildings dating from the early to mid 20th century including the Stuart Drug Store (1938) and the Hudson's Drug Store (1941). Located in the district and separately listed is the Patrick County Courthouse.