Syamzhensky District (Russian: Ся́мженский райо́н) is an administrative and municipal district (raion), one of the twenty-six in Vologda Oblast, Russia. It is located in the center of the oblast and borders with Vozhegodsky District in the north, Verkhovazhsky District in the northeast, Totemsky District in the east, Sokolsky District in the south, and with Kharovsky District in the west. The area of the district is 3,900 square kilometers (1,500 sq mi). Its administrative center is the rural locality (a selo) of Syamzha. District's population: 8,745 (2010 Census); 10,384 (2002 Census); 12,204 (1989 Census). The population of Syamzha accounts for 45.2% of the district's total population.