TWA Flight 427 was a regularly scheduled TWA passenger flight departing Lambert-St. Louis International Airport (STL) in Bridgeton, Missouri on November 22, 1994, operated using a McDonnell Douglas MD-82. On the takeoff roll it struck a Cessna 441 Conquest II, killing both of its occupants. It was the second of two flights numbered 427 that would be involved in an incident that year, the other being USAir Flight 427, which crashed in September near Pittsburgh, Pennsylvania killing all 132 on board.