Tepesomoto-La Pataste Natural Reserve (Spanish: Reserva Natural Tepesomoto-La Pataste) is a nature reserve in Nicaragua. It is one of the 78 reserves that are under official protection in the country. The reserve covers the mountain ridge running from Tepesomoto Volcano overlooking Somoto in the north, to the summit of La Pataste near Las Sabanas in the south, that forms a natural barrier between the departments of Madriz and Estelí. It reaches heights of around 1700 metres at the two peaks of Tepesomoto and La Pataste.